Archives
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br Conclusion br Acknowledgements This study was supported
2022-05-19
Conclusion Acknowledgements This study was supported by the China Postdoctoral Science Foundation (No.2015M581817), the National Research Council of Science and Technology Support Program (2015BAD03B05-06), and the Priority Academic Program Development of Jiangsu Higher Education Institutions
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Though studied less extensively than in cholangiopathies and
2022-05-19
Though studied less extensively than in cholangiopathies and fatty liver diseases, the Hh pathway is active in other forms of human liver disease, such as Schistosomiasis[58], [101] and chronic viral hepatitis,[100], [125] as well as in several animal models of liver disease, including drug-induced
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br AURK Functions br Concluding
2022-05-18
AURK Functions Concluding Remarks The AURKs are crucial regulators of cell division; however, little is known about the mechanisms by which these kinases function in meiosis. Recent work has begun to chip away at the specific roles that each of the kinases play; however, as more is uncovered,
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The opposite modulation observed for circulating LPI levels
2022-05-18
The opposite modulation observed for circulating LPI levels and WAT GPR55 Anisomycin sale by nutritional status suggests that increased levels of LPI may down-regulate the expression of its receptor in WAT, whereas in conditions of low serum LPI levels, the expression of GPR55 is stimulated. Howeve
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GLP is known to be
2022-05-18
GLP-1 is known to be expressed in a subset of taste bud cells and has been shown to co-localize with GPR120 in the circumvallate papillae [22]. Local GLP-1 regulates taste preference for sucrose [54]. Analogous to intestinal mediation of GLP-1 by GPR120, Martin et al.[22] report induction of GLP-1 s
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br Methods br Results br Discussion br
2022-05-18
Methods Results Discussion Conclusion The in vivo pEC50 for NEFA release in the rat was derived for 12 GPR81/GPR109A agonists, including the historically well-known nicotinic acid. By integrating in vitro cell assay potency data for both receptors, these in vivo pEC50 values could be rea
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br Funding M I is supported by European Research Council
2022-05-18
Funding M.I. is supported by European Research Council (ERC) Consolidator Grant 725038, Italian Association for Cancer Research (AIRC) Grant 19891, Italian Ministry of Health (MoH) Grant GR-2011-02347925, Lombardy Foundation for Biomedical Research (FRRB) Grant 2015-0010, the European Molecular B
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On the other hand it is quite possible
2022-05-18
On the other hand, it is quite possible that strychnine-sensitive glycine sites are responsible for mediating the anticonvulsant effects of GlyT1 inhibitors. Strychnine, which acts as an antagonist at these sites, is a well-known as a convulsant drug, and elevation of endogenous glycine levels at th
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nucleoside analog Given that inactivation of GLO by BAB is
2022-05-18
Given that inactivation of GLO1 by 4BAB is an active site directed mechanism, as the transition state analogue CHG protects GLO1 against inactivation by 4BAB (Figs. 2D and S6b), we next set out to determine the amino nucleoside analog that is covalently modified by 4BAB. From the X-ray crystallogra
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Another group of secreted proteins
2022-05-18
Another group of secreted proteins that determine the virulence of V. dahliae are effectors and microbe associated molecular patterns (MAMP) that regulate plant immunity [10]. So far, there is only one SEA0400 australia gene Ave1 cloned in V. dahliae, yet it does not exist in race 2 strains such as
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br Experimental br Results and discussions br
2022-05-18
Experimental Results and discussions Conclusions In this work, a novel label-free ECL biosensing method was developed to detect TDG activity using signal amplification strategy of HCR which was triggered by DNA functionalized AuNPs. The label-free ECL biosensing platform has been constructe
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Our supF forward mutation assay
2022-05-18
Our supF forward mutation assay revealed, for the first time, that 5OHU predominantly induced the C→T mutation in human cells. The mechanism underlying the induction of the C→T mutation in human cells by 5OHU remains unclear, however, the finding that 5OHU predominantly induced the C→T mutation was
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Growing evidence suggests that the
2022-05-18
Growing evidence suggests that the glycine site seems to play a pivotal role in NMDAR-related function. For example, it g protein coupled receptors has been demonstrated in a hippocampal slice study that the glycine site sub-serves the spatiotemporal detection of synaptic activity (Li et al., 2009)
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In this study for the
2022-05-18
In this study, for the first time: 1) the electrochemical glutamate oxidase-based biosensor was optimized for the determination of low micromolar glutamate concentrations; 2) the algorithm of the analysis of exocytotic and transporter–mediated glutamate release was developed; 3) the comparative anal
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Glucose uptake a critical metabolic
2022-05-18
Glucose uptake, a critical metabolic control point in glycolysis, is mediated by the GLUT (SLC2) family of integral membrane transporters (Mueckler and Thorens, 2013). GLUT1 (SLC2A1), one of the most well-studied members of the SLC2 family, exhibits a wide tissue distribution; cell surface expressio