• br Experimental Procedures br Acknowledgments br Bisphenol A

  2019-10-05

  

  Experimental Procedures Acknowledgments Bisphenol A (BPA) has been recognized as one of the most potent endocrine disruptors, functioning even at very low doses. Although it is anticipated that arginase inhibitor pathway receptor (ER) would mediate these effects of low-dose BPA, studies rev

• ACE also known as Kininase II is an important enzyme

  2019-10-05

  

  ACE also known as Kininase II is an important enzyme of the Renin angiotensin Fmoc-Tyr(tBu)-OH system (RAAS) (Novo et al., 1987), it is believed to be a potent blood pressure regulator and also plays a crucial role in activation of the bradykinin receptor via inactivation of bradykinin which works

• br Significance Our understanding of the ubiquitin biology h

  2019-10-04

  

  Significance Our understanding of the ubiquitin biology has been rapidly expanding. The role of the ubiquitin system in the pathogenesis of numerous disease states has increased the interest in finding new strategies to pharmacologically interfere with the enzymes responsible of the ubiquitinatio

• br Cytokines and NK cells br Combined effects of

  2019-10-04

  

  Cytokines and NK cells Combined effects of cytokines and other stimuli on NK cell function Cytokine-stimulated NK Resiquimod have enhanced capacity to kill tumor cells. However, usually, individual cytokines do not seem to be sufficient for full activation, proliferation, survival and effecto

• In previous works Wang et al the PR

  2019-10-04

  

  In previous works (Wang et al. [4,5]), the PR-CPA EoS has been applied to describe the solubilities of hydrocarbons (including methane, ethane, propane, n-butane, n-pentane, n-hexane, benzene, toluene, and ethyl-benzene) and mercaptans (including methyl mercaptan and ethyl mercaptan) in aqueous MDEA

• Our previous studies indicate that EBI

  2019-10-04

  

  Our previous studies indicate that EBI2 is involved in the regulation of pro-inflammatory responses and inter-cellular communication under pathophysiological conditions such as LPS challenge (Rutkowska et al., 2016b). The data showed that media taken from LPS stimulated astrocytes induces macrophage

• br Acknowledgements The authors are supported by National In

  2019-10-03

  

  Acknowledgements The authors are supported by National Institutes of Health grants (CA162804, CA92584, and CA13499 to DJC and CA166677 to BPPC) and Cancer Prevention and Research Institute of Texas (RP110465 to DJC). The cellular response to DNA double-strand break (DSB) formation is an essent

• br Conclusions There is significant interest in understandin

  2019-10-03

  

  Conclusions There is significant interest in understanding the contribution of biological mechanisms to the non-linear/bilinear dose–response curves for DNA-reactive agents. Model monofunctional alkylating agents have datasets amenable to PoD determination for genotoxic effects in both in vitro a

• The aniline R group was extensively

  2019-10-03

  

  The aniline R2 group was extensively explored and a large variety of substitution was tolerated at several positions on the aryl ring (). Notably, substitution at the 3-position often gave increased potency. Increasing lipophilic bulk at this position gave increasing potency within an ether series (

• br Conclusions In conclusion we identified and

  2019-10-02

  

  Conclusions In conclusion, we identified and overexpressed DGAT2 in fast growing, oleaginous N. oceanica for the first time. The engineered N. oceanica overexpressing DGAT2 resulted in enhanced neutral lipid accumulation and altered fatty bet inhibitor composition. Altogether, our findings demon

• In order to assess quantitatively the contribution of the un

  2019-10-02

  

  In order to assess quantitatively the contribution of the ung, dug and dut U-104 mass to uracil-DNA accumulation in E. coli, we have developed a novel method for measuring uracil residues in DNA that is based on the approach of Kow and co-workers [33] for measuring AP-sites in DNA. The method, whic

• We have previously disclosed the discovery of a azaindole

  2019-10-02

  

  We have previously disclosed the discovery of a 7-azaindole-3-acetic LY2228820 CRTh2 antagonist chemotype 1 from HTS and its subsequent optimization to give 2 as a potent and orally bioavailable inhibitor of eosinophil shape change (SC) in human whole blood. Subsequent to disclosure of that work, o

• br The contribution of Interference RNA and epigenetic in

  2019-10-02

  

  The contribution of Interference RNA and epigenetic in OA attenuation Interference RNA, a cellular mechanism for post-transcriptional gene silencing that is associated with mRNA. The potential of RNAi has successfully silenced the wide range of protein coding genes. Its high specificity sanctions

• 93 6 and br Funding br Conflict of interests br

  2019-10-01

  

  Funding Conflict of interests Introduction DAG is generated by the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) by PtdIns-specific phospholipase C (PLC) enzymes [1]. Remaining in the membrane, it binds proteins with cysteine-rich, C1 domains, and activates several of

• Several highly potent CysLT receptor antagonists

  2019-10-01

  

  Several highly potent CysLT1 receptor antagonists with large structural ras inhibitor have been developed. Beyond antagonists with structures analogous to cysteinyl leukotrienes, other subclasses comprise: (a) hydroxyacetophenones, (b) indoles and indazoles, (c) quinolines, benzothiazoles, and thia

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