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Mammalian mitochondria are composed of approximately differe
2018-10-22
Mammalian mitochondria are composed of approximately 1000 different proteins, but only 13 proteins are encoded by the mitochondrial genome. We selected Atp5g, Atp8 and Ucp2 as protein markers of the mitochondrial genome. We observed progressively higher expression of Ucp2, Atp5g and Atp8 in hiPSCs,
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The functional roles of SOX in human pluripotency maintenanc
2018-10-22
The functional roles of SOX2 in human pluripotency maintenance and lineage differentiation were recently reported (Wang et al., 2012). SOX2 is not essential for hESC self-renewal. However, overexpression of SOX2 results in the promotion of neural ectodermal differentiation and the suppression of def
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br Materials and methods br Verification and
2018-10-20
Materials and methods Verification and authentication Karyotyping and PCR-RFLP analysis were performed at Reproductive & Genetic Hospital of CITIC-Xiangya. Twenty metaphase cells were observed and all had a normal karyotype of 46, XX. The results of PCR-RFLP assay confirmed a homozygous deleti
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Electrospinning is an effective platform technique
2018-10-20
Electrospinning is an effective platform technique to produce anisotropic (aligned) fibrous scaffolds (Barnes et al., 2007), comparing to conventional methods in fabricating aligned substrates, such as soft lithography (Kim et al., 2010; McCain et al., 2014; Rao et al., 2013; Salick et al., 2014),
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Once committed to a certain cell
2018-10-20
Once committed to a certain cell fate, NPC undergo cell cycle arrest and terminal differentiation leading to the exhibition of cell-type-specific features. The onset and processes of neuronal and astroglial differentiation involve extensive chromatin remodeling and precise regulation of transcriptio
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Thus it appears that in the
2018-10-20
Thus, it appears that in the adult SVZ, in the absence or low levels of Noggin, BMP proteins expressed by astrocytes and NSC bind and activate BMPR, presumably BMPR-1A, activating its downstream SMAD proteins. Activated SMADs up-regulate the expression of the miRNA coding gene Mirg which encodes miR
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Based on our findings and the recent literature we
2018-10-20
Based on our findings and the recent literature, we propose the following model of sebocyte differentiation (Figure 7). First, subsets of LGR6- and LRIG1-expressing Dioscin Supplier residing in the upper HF and periphery of the SG constitute the bona fide stem cells of the sebocyte lineage (Page et
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br Experimental Procedures br Author Contributions br
2018-10-20
Experimental Procedures Author Contributions Acknowledgments Introduction Duchenne muscular dystrophy (DMD) is a severe muscular degenerative disease caused by loss-of-function mutations in the dystrophin gene located on the X chromosome. The dystrophin gene consists of 79 exons, and dis
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TAU fragments carry an apoptosis
2018-10-20
TAU fragments carry an apoptosis-inducing activity, which is further potentiated when tnf alpha inhibitors are exposed to TAU fragments carrying the N279K mutation (Fasulo et al., 2005). In addition, overexpression of full-length TAU carrying the N279K or the V337M mutation resulted in induction of
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br Results and Discussion br Experimental Procedures br
2018-10-20
Results and Discussion Experimental Procedures Acknowledgments We would like to thank V. Makatounakis and G. Vretzos for technical assistance, as well as I. Stratidaki for her contribution in miRNA sequencing profiling by the Ion Torrent platform (IMBB). We also thank Prof. D. Kardasis and
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Hello world!
2018-07-29
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