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Introduction Rapeseed oil production is very
2022-11-03
Introduction Rapeseed oil production is very important not only because of its application in food industry, but also in petrochemical branch. Additionally, post-extraction meal and bagasse from oilseed rape are important sources of proteins in animal feedstuffs production. Oilseed rape (Brassica n
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Furthermore stress hormones can indirectly induce DNA damage
2022-11-03
Furthermore, stress hormones can indirectly induce DNA damage, for example by altering DNA repair and transcriptional regulation of the cell cycle. It has been found that stress hormones induce the up-regulation of checkpoint kinase 1 (Chk1) and checkpoint kinase 2 (Chk2) and proto-oncogene cell div
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bace inhibitors br Introduction Clinical manifestations of
2022-11-03
Introduction Clinical manifestations of Alzheimer's disease (AD) are mainly characterized by progressive intellectual deterioration, memory impairment, cognitive impairment, and psychiatric symptoms. The pathogenesis of AD remains unclear, mainly containing genetic factors, neurotransmitter disor
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The reductase activity in patients with
2022-11-03
The 5α-reductase activity in patients with 21-OHD, as assessed by the 5α-THF to 5β-THF (ratio 3) and by the 5α-17HP to 17HP (ratio 4) ratios, showed a similar pattern of activities (Fig. 2A–C) and significant correlations (ratio 1 vs. ratio 3; rs=0.67; pgalunisertib to the 5α-reducase activity, the
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PF 04418948 Despite their different effects on
2022-11-03
Despite their different effects on cell survival, the functions of autophagy and apoptosis are not completely independent. Additionally, Cho et al. (2009) suggested that the mediation of caspase-3 links the apoptotic and autophagic signaling pathways. Consequently, to illuminate the correlation, exc
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Given that the FST protocol for mice
2022-11-02
Given that the FST protocol for mice does not engage the exposure to a previous stressful session, posits that Agtr1a levels could be kept higher by basal glutamatergic transmission rather than by stressful stimuli as postulated before. To address this possibility, we used the EMBL-EBI Expression At
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Several mechanisms of Cd induced carcinogenicity have
2022-11-01
Several mechanisms of Cd-induced carcinogenicity have been reported and are comprehensively summarized by Hartwig [32]. As early as 1980, basic science studies supported a role for endocrine disruption of AR by Cd. Donovan et al. [33], using extracts of mouse prostate cytosol, showed Cd to be the mo
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br Regulation of BCAA catabolism The BCAA
2022-11-01
Regulation of BCAA catabolism The BCAA catabolic system is equipped in mammalian cells to dispose of excess BCAAs, presumably resulting in relatively stable concentrations of BCAAs in blood and tissues in humans. The main BCAA catabolic pathway is localized in the mitochondria of all tissues. The
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AdipoR and AdipoR have been reported to be present
2022-11-01
AdipoR1 and AdipoR2 have been reported to be present in almost all type of tissues and low nitric oxide synthase inhibitor levels have been observed in white adipose tissue (Inukai et al., 2005). These receptors have been observed to become deregulated with the onset of obesity, resulting in a reduc
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In chicken ovary the adiponectin gene was found to
2022-11-01
In chicken ovary, the adiponectin gene was found to be mainly expressed in theca cells and is suggested to exert a paracrine or autocrine effect on ovarian steroidogenesis (Chabrolle et al., 2007). A limited number of studies have revealed the effect of adiponectin on ovarian steroidogenesis or its
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Adenosine receptors are proposed to play proangiogenic
2022-11-01
Adenosine receptors are proposed to play proangiogenic role in vascular and immune farnesoid x receptor within microenvironment of hypoxic tissues to maintain tissue oxygenation in chronic ischemic condition [9]. Adenosine also stimulates the production of angiopoetin-1, VEGF and Interleukin-6 (IL6
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In an AP scenario several inflammatory mediators
2022-11-01
In an AP scenario, several inflammatory mediators are produced locally to orchestrate an immune response. Eicosanoids are among those molecules and represent a class of lipid mediators synthesized from arachidonic Amoxicillin through the action of cyclooxygenases or lipoxygenases to generate prosta
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Among the AXL positive tumors that
2022-11-01
Among the AXL-positive tumors that we screened, the TNBC cell line MDA-MB-231 showed the highest AXL expression level. Additionally, AXL protein levels were higher in TNBC patient samples than in other breast cancers. Considering the difficulty of, and the urgent need for, effective treatments of T
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PPDA sale We also showed that steatosis induced an additiona
2022-11-01
We also showed that steatosis induced an additional increase of ASK1 activation that was associated to the exacerbation of hepatocyte and liver damage and was unrelated to ER stress. Indeed, several settings, also different to ER stress, can induce ASK1 activation and many of them involve oxidative
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Antioxidative enzymes such as SOD and CAT play prominent
2022-11-01
Antioxidative enzymes such as SOD and CAT play prominent roles in protecting against oxidative stress and extending food freshness due to their ability in scavenging active oxygen species for maintaining cell membrane integrity. Evidence shows that activities of SOD and CAT are positively affected b
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