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It is extremely difficult to predict a plausible
2022-04-20
It is extremely difficult to predict a plausible conformer of hsGCαβ heterodimer with right orientation of multiple domains. Even though the template identities in case of dimeric domains were not high enough but still we modelled the entire heterodimeric structure of hsGCαβ with a reasonable and ju
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GSTP c C T SNP was genotyped in
2022-04-20
GSTP1 c.341C > T SNP was genotyped in 90 patients tumor and 180 normal healthy individuals. The profile of GSTP1 c.341C > T (-)-Huperzine A and genotypes is shown in Table 2. The profile of the genotypes was in agreement with Hardy-Weinberg equilibrium (χ2 = 2.11). Minor allele frequency (341T) amo
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br Conflict of interest statements br
2022-04-20
Conflict of interest statements Acknowledgements Introduction Oral squamous cell carcinoma (OSCC) is the sixth most common cancer worldwide and is the major cause for cancer morbidity and mortality in developing countries. Age standardized incidence rate in India is 12.6 per 100 000 populat
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5,8,11-Eicosatriynoic Acid GLP is an intestinal peptide horm
2022-04-20
GLP-1 is an intestinal peptide hormone that is released by the gut following ingestion of food, particularly 5,8,11-Eicosatriynoic Acid and fats. Following its release, GLP-1 stimulates pancreatic β-cells to secrete insulin (Hirasawa et al., 2005, Covington et al., 2006). Originally, GLP-1 acted in
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The HIV genome encodes for a variety of viral
2022-04-20
The HIV-1 genome encodes for a variety of viral proteins necessary for target cell entry and viral replication. gp120 is an HIV-1 envelope glycoprotein that mediates viral particle entry by binding to cell surface receptor CD4 and co-receptors CXCR4 and/or CCR5 depending on viral tropism. While CXCR
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The results obtained through in vitro in vivo
2022-04-20
The results obtained through in vitro, in vivo and in silico corroborated with those presented by other works and indicate that CpMutY is involved in oxidative damage repair in this organism. In this regard, MutY conservation in evolutionarily distant bacteria suggests that this protein plays an imp
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Although we showed that RBL H Sc
2022-04-20
Although we showed that RBL-2H3 Sc98 Chlorhexidine digluconate took up histamine from the microenvironment, it was unclear which transporter mediated its passage across the plasma membrane. Other biogenic amines have selective transporters that belong to the neurotransmitter sodium symporter family,
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Disodium (R)-2-Hydroxyglutarate br Conflict of interest stat
2022-04-19
Conflict of interest statement Acknowledgments Introduction Hedgehog (Hh) signaling controls key steps of development in most tissues and organs of invertebrates and vertebrates (Briscoe and Therond, 2013, Ingham et al., 2011, Wilson and Chuang, 2010). The unique cellular composition and mo
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WH-4-023 Another key component of proper
2022-04-19
Another key component of proper DA cell physiology is the basal firing activity of SN DA neurons, which maintains extracellular levels of dopamine in the dorsal striatum that are essential for voluntary movement [106]. Changes in SN DA neuron activity directly impacts the amount of dopamine released
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Some clinical reports have suggested that
2022-04-19
Some clinical reports have suggested that galanin has a role in the neurobiology of mood disorders [[6], [7], [8], [9], [10]]. In behavioral studies, contradictory results have been reported [11,12]. For example, systemic administration of non-selective galanin receptor agonists, such as galmic [13]
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br Conclusion In the present
2022-04-19
Conclusion In the present study, we found that the majority of commercially available antibodies and antibody-based tools against galanin and its receptors that we tested do not meet validation requirements. Therefore, critical validation of these tools by the user is essential before being used
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Lentiviruses are associated with immunological impairment in
2022-04-19
Lentiviruses are associated with immunological impairment in their respective hosts, and both human immunodeficiency and feline immunodeficiency viral infections increase the likelihood of secondary bacterial infections [23], [24]. Recently, Kubes et al. [25] demonstrated that feline neutrophils exh
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For our test subjects we
2022-04-19
For our test subjects, we used established high fat diet–induced obese (eDIO) male mices T2DM models. The establishment of eDIO mice was accomplished with a 60% high fat diet ad libitum over a 14 week period (initiated at 6 weeks of age). Compared with regularly-dieted mice, the eDIO ones weigh sign
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Magtanong et al have demonstrated that MUFAs induce a ferrop
2022-04-19
Magtanong et al. (2019) have demonstrated that MUFAs induce a ferroptosis-resistant state in cells in an ACSL3 (acyl-CoA synthetase long-chain family member 3) dependent manner. They observed that MUFAs did not increase the expression of GPX4, which opposes ferroptosis. However, they blocked plasma
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br Transportation from TGN toward plasma membrane
2022-04-19
Transportation from TGN toward plasma membrane The insulin molecules are packaged along with other molecules such as C-peptides, amylin, Zn2+, ATP and GABA in synaptic-like macrovesicles (SLMVs, with the diameters of 50–100 nm) and large dense core vesicles (LDCVs, with the diameters of 200–500 n
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