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uPAR promotes cell associated proteolysis by binding to
2022-04-09
uPAR promotes cell-associated proteolysis by binding to uPA which locally converts plasminogen into active plasmin [10]. Ligand-engaged uPAR also acts as a potent regulator of cell migration and matrix attachment. Being a membrane receptor, uPAR needs to interact with extracellular matrix (ECM) prot
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br FREE FATTY ACID RECEPTOR
2022-04-09
FREE FATTY ACID RECEPTOR 1 (GPR40) G-PROTEIN-COUPLED RECEPTOR 120 CONCLUSION Free fatty AM966 synthesis receptors whose natural ligands are identified as FFAs having various lengths have been reported. They act as novel nutrient sensing receptors independent of PPARs and FABPs, and they ar
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A common feature of ferroptosis is the iron
2022-04-09
A common feature of ferroptosis is the iron-dependent accumulation of lipid-ROS and the subsequent depletion of polyunsaturated fatty GSK1016790A mg phospholipids (PUFA-PLs) [118]. The PUFA chains of membrane lipids are more susceptible to both enzymatic and non-enzymatic oxidation, which results in
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This hypothesis is in line with our phylogenetic
2022-04-09
This hypothesis is in line with our phylogenetic analysis of FBPase sequences which revealed that vertebrate FBP2 evolved significantly faster than FBP1 (Fig. 2). An average distance between FBP2 and ancestral vertebrate FBPase was higher than that for FBP1. Moreover, preliminary study on amphibia
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zj to j Previously we have isolated liver FBPase from Peloph
2022-04-09
Previously we have isolated liver FBPase from Pelophylax esculentus (former Rana esculenta, Frost et al., 2006) and characterized its kinetic properties (Dziewulska-Szwajkowska and Dzugaj, 1999) on the contrary the muscle FBPase has never been fully characterized. The primary aim of the present pape
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br Introduction Isoprenoid structures play an essential role
2022-04-09
Introduction Isoprenoid structures play an essential role in biology and over 30,000 natural products of this class are known (Greenhagen et al., 2003). Like other animals, insects require these compounds for many disparate processes, including electron transport (e.g., ubiquinones), protein glyc
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PKC does not however directly
2022-04-09
PKC does not, however, directly stimulate secretion by initiating calcium influx into the cell [51]. Work from multiple groups measuring calcium currents has shown that PMA alone or coupled with glucose does not modulate intracellular calcium influx [34], [51], [52], [53]. Instead of contributing to
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In C elegans KDM A appears to be involved
2022-04-09
In C. elegans, KDM4A appears to be involved in H3K36me3 reduction on the X chromosome, suggesting that this protein has a relevant role in germ cell development (Figure 2A) (47). In addition, in HeLa cells, KDM4A is associated with the repression of the achaete-scute complex homologue 2 (ASCL2) gene
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One limitation of our study
2022-04-09
One limitation of our study was that all control dogs had histologic evidence of mild GI inflammation according to established WSAVA guidelines (Washabau et al., 2010), despite being apparently healthy purpose-bred research dogs housed in a controlled environment with no history of vomiting, diarrh
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The urinary levels of OHP among the exposed
2022-04-08
The urinary levels of 1-OHP among the exposed workers were higher than those reported for a Brazilian group of charcoal workers (0.07 μmol mol creatinine) exposed to wood smoke (Kato et al., 2004), and for nonsmoking bus drivers (0.19 μmol mol creatinine) and nonsmoking mail carriers (0.11 μmol mol
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In an attempt to gain increased
2022-04-08
In an attempt to gain increased molecular insights into in vivo transmigration of neutrophils, we applied an aseptic inflammatory skin chamber model. In this model, recruitment of neutrophils is typically associated with phenotypic changes of many plasma membrane localized adhesion receptors in peri
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Abn CBD induced changes reduced microglial cell
2022-04-08
Abn-CBD induced changes (reduced microglial cell density, Dibutyryl-cAMP, sodium salt size and a lower density of ramification) in the microglial morphology that could be compatible with a blockade of the neuroinflammation provoked by MPTPp. The absence of GPR55 transcripts in microglial cells in s
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Compounds and were synthesized according
2022-04-08
Compounds –, , and were synthesized according to . The synthesis of compounds – commences with C-acylation of 3,4-dibromothiophene to the form ketone , the ring closure to form the ester , Hiyama cross-coupling or Suzki cross-coupling to produce , or to , respectively. Compound was produced from
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PBIT The PCR based analysis of TRECs in general is laborious
2022-04-08
The PCR-based analysis of TRECs in general is laborious, technically challenging and comparison of results obtained in different laboratories is difficult as different normalization standards exist. Moreover the analysis is restricted to analysis of cell populations (Douek et al., 1998; Jamieson et
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Many studies support that the increase of P
2022-04-08
Many studies support that the increase of P4 improves embryonic survival and reduces embryonic losses in ruminants [6,[18], [19], [20]]. However, experimental results are variable, contradictory and often inconclusive results. Certain studies showed that administration of GnRH or hCG after artificia
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