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br Materials and methods br Results br Discussion Here we
2021-10-19
Materials and methods Results Discussion Here, we investigated the inhibitory effects and associated mechanisms of phloroglucinol on α-glucosidase. Our results showed that phloroglucinol reversibly inhibited α-glucosidase in a dose-dependent manner (Fig. 1), with the double-reciprocal plot
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A majority of investigations of
2021-10-19
A majority of investigations of the GCK-PFK-2/FBPase-2 interaction have taken place within cells. Immunofluorescence studies in several fixed cell lines indicate that GCK colocalizes with PFK-2/FBPase-2 in the cytoplasm following overexpression [[68], [69], [70]]. Live cell imaging conducted on Cy3.
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Based on the previous report that FXR
2021-10-18
Based on the previous report that FXR regulated PEPCK indirectly [20], we speculated that FXR may regulate gluconeogenesis by regulating some key transcription factors associated with gluconeogenesis. Finally, by using HS218 as a probe, we found that FXR binds to PGC-1α promoter and directly regulat
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Enhancer of Zeste Homolog EZH
2021-10-18
Enhancer of Zeste Homolog 2 (EZH2) is a core component of the Polycomb Repressive Complex2 (PRC2) which also includes SUZ12 and EED. PRC2 represses gene transcription through trimethylation of Lys27 of histone H3 (H3K27), and contribute to the maintenance of cell identity, artesunate regulation and
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The synthesis of substituted pyrimidinone carboxamides
2021-10-18
The synthesis of 2-substituted pyrimidinone carboxamides – is outlined in , . Treatment of readily accessible nitriles with N-methylhydroxylamine hydrochloride in the presence of XEN445 mg provided the adducts , which were subsequently reacted with diethyl acetylenedicarboxylate to afford insepara
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br Memories can last a lifetime long
2021-10-18
Memories can last a lifetime, long after the transient events have passed. The fact that information stored in the Aldicarb can outlast the environmental trigger implies that enduring cellular changes in the central nervous system underlie memory. Epigenetic modifications of DNA and chromatin str
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br Main Text Post translational modifications including
2021-10-18
Main Text Post-translational modifications including acetylation, methylation, phosphorylation, and ubiquitination, of core histones directly alter DNA-histone and histone-histone interactions and thus influence nucleosome dynamics. Tight regulation of these marks is required by cells for proper
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br Hippo pathway signalling The Hippo
2021-10-18
Hippo pathway signalling The Hippo pathway is an evolutionarily conserved signal transduction pathway regulated by cell-cell contact, cell polarity, mechanical cues, ligands of G-protein coupled receptors, and cellular CB-5083 status [10]. This pathway is linked to development, cell proliferatio
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It is noticeable that CO as well as H
2021-10-18
It is noticeable that CO as well as H. pylori suppresses apoptosis while it induces autophagy in AGS cells. The differential effects of CO on the activation of transcription factors responsible for regulating expression of apoptosis- and autophagy-related genes merit further investigation. In concl
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Ca independent release of L C glutamate and GABA
2021-10-18
Ca2+-independent release of L-[14C]glutamate and [3Н]GABA that occurs via transporters working in the reverse mode also insignificantly increased in vitamin D3 deficiency despite decreased GAT-3 and EAAC-1 folate analogue and neurotransmitter uptake efficacy Fig. 3, Fig. 6 A). However, the upward t
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br Indirect GLI antagonists br Direct GLI antagonists
2021-10-18
Indirect GLI antagonists Direct GLI antagonists Concluding remarks Targeting GLI effectors represents a promising therapeutic strategy for cancer treatment. This is particularly relevant for certain tumors, such as MB, since, although classified into four distinct molecular groups (Hh- or W
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The usefulness of GIP R antagonism for the treatment of
2021-10-18
The usefulness of GIP-R antagonism for the treatment of obesity-diabetes has been revealed in numerous studies employing knockout or chemical blockade of GIP-R signalling.*88, 89, *90, 91, 92, 93, 94, 95, 96, *97 For example, sub-chronic daily administration of (Pro3)GIP to ob/ob mice results in sig
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br Materials and methods br Results br
2021-10-18
Materials and methods Results Discussion Employment of GIPR signaling, specifically the direction of this manipulation, as a strategy to improve body weight remains a contentious subject of intense scientific investigation [22], [32], [33]. Despite the physiological benefits of GIP on Hyper
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Recent studies suggest that the biological
2021-10-18
Recent studies suggest that the biological importance of endogenous ghrelin becomes accentuated during exposure to more metabolically-constrained and stressful environments. Indeed, mice lacking either ghrelin or GHSR demonstrate impaired ability to adapt metabolically and/or behaviorally to caloric
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In order to test whether the enhanced hyperpolarization
2021-10-18
In order to test whether the enhanced hyperpolarization in the presence of increasing amounts of extracellular Ca2+ could be due to an ionophore effect of NS309, red cell uptake of 45Ca and partition of 45Ca into a water/n-octanol phase +/−100 μM NS309 were determined. However, no indication of iono
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