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Introduction Piperine is a pungent alkaloid and accounts for
2021-03-22
Introduction Piperine is a pungent alkaloid and accounts for 2–5% dry weight in black and white peppers (Butt et al., 2013). Physiological benefits of piperine have been a subject of extensive research in recent years. Piperine is an antioxidant with strong anti-inflammatory and antiangiogenic acti
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br Activatable MRI probes MRI
2021-03-19
Activatable MRI probes MRI is commonly used in clinics around the world and has the advantages of outstanding tissue-penetration depth and extremely high spatial resolution for in vivo imaging [33]. MRI has relatively poor sensitivity and usually requires O6-Benzylguanine agents to enhance the i
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From an industrial perspective the low
2021-03-19
From an industrial perspective, the low turnover numbers and limited substrate scope of α-KG halogenases still represents a significant challenge. However, in light of the fact that currently no chemical processes are available for the selective halogenation of aliphatic carbon centers in complex mo
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Remoxipride hydrochloride br Conflict of interest statement
2021-03-19
Conflict of interest statement Introduction Endothelins (ETs) are a family of multifunctional, naturally occurring peptides with long-lasting vasoconstrictor and pressor effects (Zhou et al., 2004). They are synthesized as a large protein, the pre-proET-1 or Big ET-1, which is subsequently cle
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Tailoring pharmacological treatment to the genetic backgroun
2021-03-19
Tailoring pharmacological treatment to the genetic background of a person can enhance therapeutic response (), increase compliance (), and decrease drug toxicity (, , ). Because cocaine addiction has a strong genetic basis, with the vulnerability to develop an addiction estimated to be as high as 72
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A previous report demonstrated that DA dependent
2021-03-19
A previous report demonstrated that DA-dependent oxidative stress may be the initial event in MA neurotoxicity (Cubells et al., 1994). Oxidative burdens at early stage might be a prerequisite for neurotoxic scenarios induced by 3-FMA, and they are in line with MA case (Shin et al., 2012, Shin et al.
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The excitatory amino acid L glutamate or glutamate mediates
2021-03-19
The excitatory amino FMK L-glutamate or glutamate mediates most of the excitatory neurotransmission within the mammalian central nervous system (CNS) and has been implicated in numerous peripheral nervous system (PNS) pathways. The excitatory amino acids, including glutamate, are of great physiolog
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br Pre clinical combination studies using CSF CSF R
2021-03-19
Pre-clinical combination studies using CSF-1/CSF-1R inhibitors In preclinical models, the CSF-1R pathway can be blocked by using either small molecule kinase inhibitors (GW2580 [30], PLX3397 [31], Ki20227 [32], BLZ945 [33] and CYC11645 [34]), antibody-mediated inhibition of CSF-1 using 5A1 [35] o
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br Results br Discussion GPCRs
2021-03-19
Results Discussion GPCRs recognize a broad range of molecules with a vast chemical nmda receptor antagonist through different mechanisms. Our understanding of the recognition of lipid mediators by GPCRs primarily comes from the structural studies of receptors for lysophospholipids and endocann
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Our results for imidacloprid were
2021-03-19
Our results for imidacloprid were unexpected: considering that imidacloprid (Im) is a neonicotinoid insecticide with a different mode of action (agonist of the nicotinic TASIN-1 receptor) than OPs, we expected Es-ChE and T-ChE activity to be largely insensitive to changes in Im concentrations. Howe
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br Conflict of interest statement br References and
2021-03-18
Conflict of interest statement References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as: Acknowledgements We acknowledge financial support by the Swiss State Secretariat for Education, Research and Innovation (Federal
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br Acknowledgements This study was financially supported by
2021-03-18
Acknowledgements This study was financially supported by the National Special Research Programs for Non-Profit Trades (Agriculture) (Grant No. 201303045) and the Basic Foundation for Scientific Research of the State-level Public Welfare Institutes of China (Grant No. 2013JB10). Introduction L
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PRRSV is a single stranded positive sense enveloped RNA
2021-03-18
PRRSV is a single-stranded, positive-sense enveloped RNA virus in the family Arteriviridae of the order Nidovirales (Meng et al., 1994, 1996). The PRRSV 5-Methoxy-UTP australia is approximately 15 kb in length and contains eleven known open reading frames (ORFs) (Snijder et al., 2013). The 3′ end o
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Programmed cellular death or apoptosis
2021-03-18
Programmed cellular death or apoptosis is a process genetically controlled that plays an important role in cellular homeostasis, being an important defense mechanism to remove cells that have been infected, damaged or mutated (Smith and Smith, 2012, Wlodkowic et al., 2011). Nevertheless, apoptosis s
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thapsigargin receptor Our study showed that parental morphin
2021-03-18
Our study showed that parental morphine exposure in the adulthood is associated with an increased tendency toward morphine consumption in F1 but not F2 male offspring. Thus, it seems that trans-generational effects of parental morphine consumption disappear in the second generation. In support of ou
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