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br Conclusions br Acknowledgment br Introduction The role of
2021-01-14
Conclusions Acknowledgment Introduction The role of cholesterol metabolism during multiple sclerosis (MS) is debated and the underlying physiopathology largely unknown. Dyslipidaemia is associated with worsening inflammatory activity and MS disease progression [1], [2], [3]. In the mouse mo
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The BMP family comprises significant growth factors for the
2021-01-14
The BMP family comprises significant growth factors for the regeneration of bone and cartilage. Among these, BMP- has been known as an early marker during the proliferation of osteoblast cells, and one of the most potent stimulators of osteoblastic cells differentiation [40]. Studies with COX-2 knoc
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Experiments on the rat model of E coli
2021-01-14
Experiments on the rat model of E. coli pyelonephritis, performed to investigate the relationship between the acute inflammatory processes and the permanent kidney damage (Brooks et al., 1974), have demonstrated a positive correlation between the degree of free radical-mediated renal injury and the
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Another important mediator in fear learning is the neuropept
2021-01-14
Another important mediator in fear learning is the neuropeptide corticotropin-releasing factor (CRF). For example, local repeated administration of CRF into the basolateral amygdala potentiates the acquisition of cue-conditioned fear (Bijlsma et al., 2011) and CRF1 receptor antagonists effectively
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Various domains of the HSA molecule
2021-01-14
Various domains of the HSA molecule have also been used to make bioconjugates with increased stability, better targeting properties, and/or extended half-lives in blood. For example, domain I of HSA has been used in the preparation of antibody conjugates. This was achieved through the use of a cyclo
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Raloxifene is a second generation
2021-01-14
Raloxifene is a second generation SERM that has tissue-specific effects that differ from those of tamoxifen. Raloxifene was marketed for prevention and treatment of osteoporosis in postmenopausal women in the US and Europe. In a phase II randomized double-blind study, tamoxifen and raloxifene were e
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This approach is similar to that suggested by
2021-01-14
This approach is similar to that suggested by the previous edition of the GL [6]. Not surprisingly, the questions to be answered are the same (i.e., was the event TLOC? In cases of TLOC, is this am580 of syncopal or non-syncopal origin? In cases of suspected syncope, is there a clear aetiological d
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Several studies on the collagen receptor DDR have
2021-01-13
Several studies on the collagen receptor DDR1 have revealed a defined collagen signaling pathway that causes cell scattering and cadherin switching. As mentioned earlier, DDR Fenoprofen Calcium on collagens are distinct from integrin binding sites; therefore, the same collagen protein can bind to DD
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br As mentioned above defects
2021-01-13
As mentioned above, defects in the DNA ligase IIIα-interacting protein TDP1 have been identified as the cause of the hereditary neurodegenerative disease, spinocerebellar ataxia with axonal neuropathy 1 (El-Khamisy et al., 2005). In addition, defects in two other DNA repair proteins, aprataxin and
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Introduction DHFR is an important enzyme in both mammals
2021-01-13
Introduction DHFR is an important enzyme in both mammals and microorganism including Mycobacterium tuberculosis (Mtb). It catalyzes folic positive people conversion to dihydro and tetrahydro folic acid which is a crucial step in folate pathway [1]. Inhibition of folate pathway leads to interruptio
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There is literature precedence for the metabolic
2021-01-13
There is literature precedence for the metabolic activation of the methylene carbons adjacent to the ring oxygen(s) of dioxanes and benzopyrans resulting in ring-opened electrophilic carbonyl species. Based on the potential for this metabolic pathway being operative with , a steric block approach wa
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This review focuses on the atomic basis of CRM
2021-01-13
This review focuses on the atomic basis of CRM1-mediated nuclear export. There are now 27 crystal structures of CRM1 in the Protein Data Bank (PDB) (www.rcsb.org) [64]. Collectively, this large body of work explains various aspects of CRM1 function. Here we summarize the structure–function studies t
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br Experimental procedures br Introduction Perfluorooctane s
2021-01-13
Experimental procedures Introduction Perfluorooctane sulfonate (PFOS) is an anthropogenic compound with high thermal, chemical and biological stability, which makes it a perfect ingredient for many industrial applications (Kissa, 2001). Nevertheless, these characteristics also mean that PFOS i
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br Methods br Results br Discussion The lowest intra
2021-01-13
Methods Results Discussion The lowest intra-CeA dose of R278995/CRA0450 that prevented the elevations in 2825 reward thresholds associated with nicotine withdrawal was 0.05μg/side (0.1μg total bilateral dose). The total bilateral dose in the present study is 100 times lower than the lowest
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In previous works Wang et
2021-01-13
In previous works (Wang et al. [4,5]), the PR-CPA EoS has been applied to describe the solubilities of hydrocarbons (including methane, ethane, propane, n-butane, n-pentane, n-hexane, benzene, toluene, and ethyl-benzene) and mercaptans (including methyl mercaptan and ethyl mercaptan) in aqueous MDEA
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