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A similar pattern was observed for both tissues
2020-08-19
A similar pattern was observed for both tissues of P. harpagos, evidencing the absolute predominance of acetylcholinesterase. As observed, no effects were attributed to Iso-OMPA. The hypothesis that the major cholinesterasic form is AChE was reinforced considering the higher hydrolytic activity, whi
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Finally we have determined for the first
2020-08-19
Finally, we have determined for the first time that aromatase enzyme activity is necessary to observe IGF-1-dependent Venlafaxine receptor activation. Neuroestrogen synthesis has been shown to be important for the maintenance of synaptic spine density in hippocampal slice cultures (Kretz et al., 200
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In countries such as China where there is a
2020-08-19
In countries such as China where there is a high commercial production of rice, the use of rice husk ash (RHA) as an alternative cementing material can become a great asset for environmental rehabilitation and address the difficult disposal issues associated with this agricultural waste [23]. RHA po
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EP is the major receptor to mediate
2020-08-19
EP4 is the major receptor to mediate PGE2-induced inflammatory pain. EP4 is upregulated by DPP4 Activity Fluorometric Assay Kit in DRG neurons [16]. Intrathecal injection of the EP4 agonist produced pain responses [25]. Either systemic or local injection of EP4 antagonists relieves inflammatory pai
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Importantly our in vivo data fit to
2020-08-19
Importantly, our in vivo data fit to the in vitro data, further confirming the synergistic effect of XJD and gefitinib on the inhibition of lung cancer and the regulation of SP1, HOTAIR, and EP4 AP1903 levels. The doses of XJD used were based on our previous in vivo study (Zhao et al., 2016). We be
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Acanthopanax senticosus Rupr Maxim Harms a nontoxic herb bel
2020-08-18
Acanthopanax senticosus (Rupr. & Maxim.) Harms, a nontoxic herb belongs to the family of Araliaceae, which found in Northeast Asia. A. senticosus traditionally used as a tonic to treat rheumatism, diabetes, and hepatitis [7]. Previous phytochemical and biological investigations found its roots and s
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br Conclusions br Conflict of
2020-08-18
Conclusions Conflict of interest Financial disclosure Introduction In prokaryotes, six distinct autotrophic CO2 fixation pathways have been identified so far. Of these pathways, 3-hydroxypropionate/4-hydroxybutyrate (3-HP/4-HB) cycle is one of the recently discovered pathways [1]. The 3-
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br Expression and Purification of
2020-08-18
Expression and Purification of Atg4 and Atg8 Proteins for In Vitro Assays Measurement of Atg4 Activity In Vitro and Ex Vivo Kinetics Analysis of Atg4 Enzymes Summary Atg4 proteases play a crucial role in preparing Atg8 for conjugation to lipid membranes and for the deconjugation of Atg8
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In summary our findings indicate that bFGF stimulates
2020-08-18
In summary, our findings indicate that bFGF stimulates CPT1 expression, FA oxidation and lactate production with the participation of PPARβ/δ activation. On the other hand, this investigation shows that FSH concomitantly regulates the expression of genes involved in FA metabolism and in mitochondria
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Iris domestica L Goldblatt Mabb syn Belamcanda chinensis L
2020-08-18
Iris domestica (L.) Goldblatt & Mabb. (syn. Belamcanda chinensis L.) DC. (Iridaceae) occurs naturally in South and East Asia. Despite the fact that former monotypic genus Belamcanda has been included in the extended genus Iris, this classification has been questioned (Wilson, 2011; Mavrodiev et al.,
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Soon after the discovery of ET and the cloning
2020-08-18
Soon after the discovery of ET1 and the cloning of its ETA and ETB receptors, low-molecular-weight compounds were identified that can prevent the binding and effects of radioactively labeled ET1 3, 5, 6, 8. Initially, these ERAs resulted from screening efforts (e.g. BQ123 39, 49 and bosentan [50]).
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br No Evidence for Further
2020-08-18
No Evidence for Further ET-Receptor Subtypes Further receptor subclassifications have been proposed including suggestions that ETB could be subdivided into ETB1, present on endothelial cells, and ETB2 on smooth muscle cells, but there currently is no evidence that the receptors expressed by these
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br Conclusion The results of the current
2020-08-17
Conclusion The results of the current study show that boldness is associated with higher gene expression of drd2a, drd2b and oprd1b in zebrafish males. The results are correlational and additional experiments are needed to clarify the causal role of these receptors in zebrafish behavior. Confl
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Mechanistically GW treatment modulated cytokine
2020-08-17
Mechanistically, GW2580 treatment modulated cytokine expression within the kidney. We noted a decrease in the levels of TNF, MCP-1, IL-1β, IL-27, and GM-CSF in GW2580 treated mice. Decreased levels of these proinflammatory cytokines likely contributed to the attenuated proteinuria and improved renal
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In our previous research we have focused
2020-08-17
In our previous research, we have focused on the discovery of novel VEGFR-2 inhibitors as anti-angiogenesis agents. Numbers of biphenyl-aryl urea incorporated with salicylaldoxime including BPS-7 have been developed as potent and selective VEGFR-2 inhibitors (Fig. 3) [12], [13], [14], [15], [16], [1
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