• One possibility to differentiate between the two failure mod

  2019-07-02

  

  One possibility to differentiate between the two failure modes, and also to identify the corresponding characteristics of the resulting fracture surface, is a series of FNCT measurements with varying nominal (initial) stress. The dependence of the observed time to failure tf on the actual stress cha

• In this paper we focused

  2019-07-02

  

  In this paper, we focused on Ewing sarcoma (ES), a rapidly growing, highly malignant bone tumor developing metastases in the vast majority of patients unless multiagent chemotherapy is applied [16]. ES is the second most frequent bone tumor in childhood and adolescence, and is characterized by the p

• The role of Epac in the regulation of

  2019-07-02

  

  The role of Epac in the regulation of intracellular Ca homeostasis and contractility is still matter of debate. In rat adult cardiomyocytes, acute Epac stimulation decreased the amplitude of Ca transients [6], [9], [10] with either no changes [6] or increments [9] in cell shortening, suggesting an e

• In the present study we first examined the in vivo

  2019-07-02

  

  In the present study, we first examined the in vivo and ex vivo effects of androgens on ep1 A-769662 in the olfactory rosette of male B. sinensis. Thereafter, we cloned two different B.sinensis ar cDNAs and investigated their roles in the effects of 11-KT on ep1 expression. Material and methods

• br Results br Discussion In this paper we present

  2019-07-02

  

  Results Discussion In this paper we present insights into the observed specificities of inhibitors targeting the ubiquitin-activating and related E1 equol via crystal structures of the specific NEDD8-E1 inhibitor MLN4924, the dual NEDD8/Ub E1 inhibitor ABPA3, and the selective Ub-E1 inhibitor

• Oleandrin br Results br Discussion The origin and fate of Tf

  2019-07-02

  

  Results Discussion The origin and fate of Tfh cells has been intensely studied since their first description 14 years ago (Breitfeld et al., 2000, Schaerli et al., 2000). Although mice engineered to report BCL6 (Kitano et al., 2011, Liu et al., 2012) and interleukin-21 (IL-21) (Lüthje et al.,

• 5,7-dihydroxychromone what A study profiling chemokine expre

  2019-07-02

  

  A study profiling chemokine expression in LCLs revealed high expression levels of CCR6, CCR7, and CCR10 and low expression of CXCR4 and CXCR5 in EBV immortalized cells. Accordingly, LCLs showed a markedly increase in migration in response to the ligands of CCR6 (CCL20), CC7 (CCL21), and CCR10 (CCL28

• Confidence with which data of animal safety toxicity studies

  2019-07-01

  

  Confidence with which data of animal safety/toxicity studies can be translated to human depends upon the knowledge that whether humans would be exposed to similar chemical entities (parent and its metabolites) as the animals exposed during toxicity studies. In this regard, in vitro qualitative evalu

• br Discussion The present study found cholinesterase activit

  2019-07-01

  

  Discussion The present study found cholinesterase activity in Saccostrea sp. to vary significantly among three tissue types (digestive gland, gills, adductor muscle) and to respond differentially to four toxicants, three of which were non-organophosphates. Furthermore, a comparison of enzyme act

• Catheter ablation was performed from the basal

  2019-07-01

  

  Catheter ablation was performed from the basal septum to the apex in the sites where the right bundle branch potential could be recorded. Radiofrequency (RF) hsp90 inhibitor was delivered with a temperature controlled 4-mm-tip deflectable catheter (Biosense Webster, Diamond Bar, CA, USA) with a tar

• orexin In order to treat metastatic bone disease effectively

  2019-07-01

  

  In order to treat metastatic bone disease effectively all steps involved in the metastatic cascade need to be taken into account as for example the interactions between primary and secondary sites, tumour cell–bone cell cross talk and osteomimicri [8]. Therefore, concomitant targeting of both the tu

• br Methods br Results br Discussion

  2019-07-01

  

  Methods Results Discussion Bisphosphonates reduce skeletal morbidity in patients with advanced cancers involving bone and have become a recommended component of the multidisciplinary treatment of MBD [1]. However, bone-health benefits have not generally translated into significantly improve

• Approximately of the patients who developed

  2019-07-01

  

  Approximately 50% of the patients who developed BM during their palliative disease course received BM-related radiotherapy and/or surgery; 12% of the patients received both therapy options. Our data confirms that the majority of patients with BM will respond to a low course of radiotherapy with good

• In the phase AZURE trial women were

  2019-07-01

  

  In the phase 3 AZURE trial, 3360 women were randomly assigned to receive standard adjuvant systemic treatment alone (control group) or with 4mg intravenous zoledronic ack1 inhibitors every 3–4 weeks for 6 doses, then every 3 months for 8 doses, followed by every 6 months for 5 doses, for a total of

• It is noted that in this

  2019-07-01

  

  It is noted that in this study BrS patients had an abnormality of plasma K+ concentration which has been suggested to be a potential trigger of Brugada Syndrome episodes [11]. In the absence of renal dysfunction, the hyperkalemia may result from an abnormal phenotype in BrS characterized by mutation

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