• br Experimental Procedures br Author Contributions br Acknow

  2018-11-02

  

  Experimental Procedures Author Contributions Acknowledgments Introduction In recent years, a number of small molecules have been identified that control stem cell differentiation and/or cell reprogramming. Surprisingly, only a few metabolites have been identified in this context, possibl

• Interferons are a diverse family of cytokines

  2018-11-02

  

  Interferons are a diverse family of cytokines which possess antiviral and immunomodulatory properties (Isaacs and Lindenmann, 1957; Stark et al., 1998; Theofilopoulos et al., 2005). These specialized proteins are produced by cells in response to viral infection. Cellular sensors such as retinoic ccr

• actin polymerization inhibitor CBP is implicated in differen

  2018-11-02

  

  CBP is implicated in different biological functions with an essential role in maintaining normal germ cells development. CBP is expressed in primordial germ cells (PGCs) and in ESCs but is highly expressed in PGCs compared with ESCs. Proper levels of CBP have been shown to be important for hematopoi

• Introduction Osteoprogenitor cells are ubiquitous multipoten

  2018-11-02

  

  Introduction Osteoprogenitor cells are ubiquitous, multipotent stromal cells capable of differentiating into multiple cellular lineages [e.g. osteoblasts (responsible for secretion of the extracellular bone matrix) and osteocytes (mature bone cells)], and replenish existing local cell populations (

• Although WNT signaling plays a prominent

  2018-11-02

  

  Although WNT signaling plays a prominent role in A/P patterning of the neural tube, few studies have extensively examined the influence of WNT on the A/P positional identity of hPSC-derived NPCs and neurons. To date, most studies have relied on FGF8 (Yan et al., 2005; Yang et al., 2008) or retinoic

• Since we focused on the

  2018-11-02

  

  Since we focused on the pathology of NMJ, we performed a detailed examination of our NMJ-LS. To evaluate whether the developmental status of the MNs affects the NMJ pathology, we evaluated AChR clustering at three different time points and obtained consistent data. In addition to impaired AChR clust

• Among the epigenetic aberrations of iPSCs DNA methylation

  2018-11-02

  

  Among the epigenetic aberrations of iPSCs, DNA methylation is of particular importance. Previous studies showed that unique de novo differentially methylated (DMR) or hydroxymethylated regions (hDMR) are present in iPSCs compared with hESCs (Lister et al., 2011; Wang et al., 2013). Furthermore, the

• br Results br Discussion Hepatocyte like

  2018-11-02

  

  Results Discussion Hepatocyte-like cells generated from iPSCs can be used to model liver development and disease, for toxicity studies, and potentially could offer a source of hepatocytes for cell therapy (Rashid et al., 2010; Delaforest et al., 2011; Cayo et al., 2012; Fox et al., 2014). Whil

• Here we provide the first definitive evidence

  2018-11-02

  

  Here we provide the first definitive evidence that an alternative airway progenitor cell, marked by expression of SOX2, is the predominant cell of origin for nascent KRT5+ pak1 after influenza infection. This was true for nascent KRT5+ cells that emerge in the airways and those that appear later in

• br This result is not unexpected as the Crocco Eq

  2018-11-02

  

  This result is not unexpected, as the Crocco Eq. (3) is equivalent to a canonical system. A similar result is obtained when splitting series in the case of the Blasius equation: which is not connected to any variational problems. Furthermore, let y be and the split linear system takes the form

• Analysis of the data in Fig b shows

  2018-11-02

  

  Analysis of the data in Fig. 3b shows that the shape of the (222) reflection virtually does not change and corresponds to the instrumental resolution at all temperatures. The right shoulder of the (310) peak exhibits slight differences from the instrumental resolution even at high temperatures, whic

• This study has limitations It is possible that

  2018-11-02

  

  This study has limitations. It is possible that we are missing information on key determinants of postpartum AL such as a pre-pregnancy history of cardiovascular disease or pre-pregnancy chronic disease. As we enrolled women postpartum and the focus of our analyses are on the postpartum period, we w

• Some studies have shown improvement

  2018-11-02

  

  Some studies have shown improvement in insomnia following an anti-stress massage [22,23]. It has also been reported that women experiencing insomnia as a symptom of menopause tend to select alternative therapies, particularly body therapies, as their first choice of therapy [24]. In a recent pilot s

• faah inhibitor Here the calcined iron oxide

  2018-11-01

  

  Here, the calcined iron oxide nanoparticles have significant properties such as large surface area (surface-to-volume ratio), non-toxicity, chemical stability, and high electrical conductivity; which offered high faah inhibitor communication features that enhanced the direct electron communication

• br Materials and method The Real Time

  2018-11-01

  

  Materials and method The Real Time PCR data have been collected by using the miniaturised platform Q3 Real Time PCR (Fig. 1). This system is based on silicon microchip able to perform Real Time PCR analysis in compact and portable way. More specifically, the platform is composed by the following

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