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sphingosine kinase The mechanism leading to the gelatinous t
2019-05-27
The mechanism leading to the gelatinous transformation may involve inhibition of tyrosine kinase activity by tyrosine kinase inhibitors (TKI) leading to blockage of downstream signal pathways, affecting extracellular matrix deposition, adipocyte differentiation and angiogenesis. Moreover, the catabo
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In conclusion we demonstrated that cells with
2019-05-27
In conclusion, we demonstrated that nuciferine with the standard Ph had no detectable BCR–ABL1 KD mutations and that they were responsive to imatinib therapy, while cells with the variant translocation harbored two KD mutations, a previously described one and a never previously reported one [5]. Th
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Pharmacological inhibition of PI K induces apoptosis of CLL
2019-05-27
Pharmacological inhibition of PI3Kα induces apoptosis of CLL rho kinase inhibitors in vitro [5,18], and inhibits CLL migration towards CXCL12 [5]. The PI3Kα/δ inhibitor copanlisib induces significantly greater apoptosis of CLL cells compared to idelalisib (IC50 of 450nM and >10μM, respectively) in
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blasticidin But consider the alternative outcomes
2019-05-27
But consider the alternative outcomes of so-called virtuous plate-clearing. If the additional portion does not displace other consumption—ie, the amount eaten subsequently is not reduced—then total consumption will have increased. A lack of displacement means no reduction in demand for agricultural
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There was a modest excess risk of mortality
2019-05-27
There was a modest excess risk of mortality associated with multidrug-resistant organisms, which was lower than that previously recorded in south Asia. There are methodological challenges in the attribution of excess neonatal mortality with antimicrobial resistance because of known confounding with
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There was a modest excess risk of mortality
2019-05-27
There was a modest excess risk of mortality associated with multidrug-resistant organisms, which was lower than that previously recorded in south Asia. There are methodological challenges in the attribution of excess neonatal mortality with antimicrobial resistance because of known confounding with
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This population based study demonstrates
2019-05-27
This population-based study demonstrates that interventions must change attitudes regarding violence in the home and society, promote positive parenting practices, and tackle the inequality that allows the normalisation of violence and patriarchal power over women and children. Violence does not occ
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OSA is a risk factor for hypertension and stroke
2019-05-27
OSA is a risk factor for hypertension and stroke in particular [6,7]. Continuous positive airway pressure (CPAP) treatment reduces deaths and cardiovascular events, and improves hypertension control [8,9]. The role of CPAP therapy on the treatment of cardiac arrhythmia is still limited. Here, we rep
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Bacterial LPS stimulates monocytes and tissue macrophages to
2019-05-24
Bacterial LPS stimulates monocytes and tissue macrophages to release TNF-α and IL-1, which then stimulate secondary response cytokines, including IL-6. In addition to hematopoietic cells, IL-6 is synthesized by many different types of nonhematopoietic cells, including endothelium, lasting for an ext
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A number of studies have shown that zoledronic acid
2019-05-24
A number of studies have shown that zoledronic neurokinin receptor antagonist has the ability to potentiate effects of anti-tumor agents such as doxorubicin [21] or everolimus [22]. In a recent paper the combination of chemotherapy with a single infusion of 4mg zoledronic acid in patients with brea
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Hasta el tercer acto cuando Licurgo se casa y
2019-05-24
Hasta el tercer acto, cuando Licurgo se casa y vuelve congo red la racionalidad, presenta al Rey una serie de leyes, quien, sin conocerlas, le pregunta si desea hacerlas públicas, pero, desde otra óptica, Licurgo responde: Son, pues, el Rey y el Reino quienes deben acordar las leyes, para evitar ca
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Interpretation In Haiti the creation
2019-05-24
Interpretation In Haiti, the creation of a national-level, centralised registry has facilitated the diagnosis of patients with surgical heart disease; accelerated the expansion of surgical options for these patients; and has helped to catalyse the development of permanent surgical capacity in Haiti
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br Discussion Intriguingly in a
2019-05-24
Discussion Intriguingly, in a case report about elevation of skeletal enzymes in ultramarathon runners, the CK level reached its peak value one day after the run, had a ∼4-day plateau, and began to decline after a few more days. The sustained increase of plasma CK in this athlete was quite differ
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These studies demonstrated that the levels of essential mine
2019-05-24
These studies demonstrated that the levels of essential lpa receptor in healthy pregnant women were significantly different from those of the general population. There is a need to evaluate more pregnant women, especially from different races, for the purpose of establishing specific normative leve
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br Material and methods br Results
2019-05-24
Material and methods Results Discussion The present study provides clinical, molecular, and in vitro electro-physiological evidence that a rare SNP (KCNE1-D85N) can act as a genetic modifier in LQTS. In general, SNPs are thought to be non-pathological, but some have been reported to modify
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