• The tumor microenvironment is enriched with EMVs that are

  2019-06-28

  

  The tumor microenvironment is enriched with EMVs that are derived not only by proliferating tumor cells, but also from infiltrating macrophages and neutrophils, and support tumor cell survival, growth, invasion and metastasis. Tumor derived EMVs also have the potential to modulate surrounding stroma

• Automated template matching available in some electrophysiol

  2019-06-28

  

  Automated template matching, available in some electrophysiology systems, has been used to improve pace matching in the ventricle [13]. We found that using automated analysis improved the resolution of pace mapping, especially with bipolar EGMs. The matching algorithms are relatively simple and not

• Transformation of sanitation related knowledge into routine

  2019-06-28

  

  Transformation of sanitation-related knowledge into routine practice is hindered by traditional mindsets and the absence of awareness and an attitude to learn. Poverty has been described as a barrier to following safe hygiene practices. Regular use of footwear is equally important for the prevention

• This trial included patients who met the ICD

  2019-06-27

  

  This trial included 1500 patients, who met the ICD criteria for primary prevention (non-ischemic, ischemic, dual chamber ICD or CRT-D). The patients were randomized to 3 arms: (1) conventional therapy: Zone 1(VT) 170bpm, 2.5s delay, Zone 2 (VF) 200bpm, 1s delay; (2) high rate therapy: Zone 1(VT) 170

• The presence or absence of

  2019-06-27

  

  The presence or absence of atrial potentials could not be confirmed by the VEGM. Consequently, atrial potentials with atrial event markers could not be differentiated from FFRW or noise activity in the VEGM (Fig. 6). In addition, tiny suspected atrial potentials without any atrial event markers coul

• Lymphocytic infiltrates in thyroid cancer

  2019-06-27

  

  Lymphocytic infiltrates in thyroid cancer may suggest a background of chronic lymphocytic thyroiditis. Thyroiditis is characterized by a cellular immune response with dense lymphocytic infiltration of the thyroid gland, as well as by a humoral immune response leading to the production of autoantibod

• The results described thus far suggest that

  2019-06-27

  

  The results described thus far suggest that PtAF-induced atrial remodeling combined with acute atrial stretch facilitates anchoring of 3-D scroll waves to the border of atrial pectinate muscle and prolongs their life span in favor of AF maintenance. However, why is it that scroll waves anchor to the

• Common and rare SCN A variants may contribute

  2019-06-27

  

  Common and rare SCN10A variants may contribute to AF susceptibility [59,60]. SCN10A mutations (R14L and R1268Q) cause a loss of function of Nav1.5 current, which is expected to reduce excitability and lead to the development of the arrhythmogenic substrate responsible for BrS and AF. A common varian

• Si bien esta amerita un an

  2019-06-27

  

  Si bien esta amerita un análisis detallado, me detendré en algunas cuestiones que considero clave para entender el modo en cómo resuelve Vigil la integración del pasado colonial. En primer lugar, aparece ya una clara intención de situar endothelin receptor éste como los orígenes de lo que será la n

• Brasil y Argentina son los dos pa ses que

  2019-06-27

  

  Brasil y Argentina son los dos países que comparten fronteras con todos los países restantes del bloque primigenio. Aun así, sus legislaciones abordan el tema en menor profundidad en comparación Mefloquine hydrochloride structure como lo hacen Paraguay y Uruguay. En Brasil, la Ley 11445 es la que re

• Cuando Gonzalo Pizarro se alz en el Per nunca mostr

  2019-06-27

  

  Cuando Gonzalo Pizarro se alzó en el Perú, nunca mostró intenciones de romper los vínculos que lo unían Pranlukast su rey, por mucho que su plan fuese establecer una monarquía, autónoma de la castellana, que gobernaría el territorio. En las misivas que envió al monarca, Pizarro confirmaba su obedien

• Upon diagnosis the patient s

  2019-06-27

  

  Upon diagnosis, the patient׳s lymphoma and HLH represented a therapeutic dilemma. Effective early therapy reduces mortality of HLH from 95% to 30–35% [4]. The HLH-2004 treatment protocol consists of T-cell targeted immunosupression with dexamethasone and cyclosporine, macrophage targeted etoposide w

• br es resultado de una larga investigaci n de la

  2019-06-26

  

  es resultado de una larga investigación de la obra de Juan Rulfo, pero es asimismo el fruto de largas reflexiones sobre “el arte de narrar” en general y sobre las relaciones que la literatura entabla con la cultura y la historia en que se inscribe, conexiones ellas mismas históricas. Desde el artí

• El ansia renovadora que suscita

  2019-06-26

  

  El ansia renovadora que suscita también se crea y re-crea en los paratextos ilustrados, que en cierto modo también sugieren una performatividad discursiva aplicada a la realidad convulsa de México en la revista Futuro, que puede observarse en la imagen y que se ha titulado, “Defensores del orden”.

• Advani et al reported that CsA

  2019-06-26

  

  Advani et al. reported that CsA was associated with good overall and durable responses. Although the mechanism remains unclear, CsA may inhibit the function of T cells, including their production of cytokines involved in the progression of AITL. Consequently, immunosuppressive therapies might exacer

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