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Traditionally ER is considered the preponderant ER form in
2020-08-06
Traditionally, ERβ is considered the preponderant ER form in the lung [3]. ERβ’s relation to patients’ survival remains controversial [26], [27]. ERα mRNA and protein have also been detected in lung tumor specimens and cell lines [18], [26], [28]. Biologically-active ERα spliced variants have been d
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Conoidin A mg The relationship of DDR expression to tumor ag
2020-08-05
The relationship of DDR1 Conoidin A mg to tumor aggressiveness or patient outcome has been investigated for other types of cancer, but these other investigations have typically only considered expression of tDDR1 protein. For example, Quan et al. reported that the DDR1 protein was highly expressed i
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br The regulation of DNA PK activity
2020-08-05
The regulation of DNA-PK activity How DNA-PK is activated or deactivated in response to DNA damage and other cellular stress, is still relatively unknown [38]. Previous studies have shown that two serine/threonine protein phosphatase PP5 and PP6 are involved in DNA-PK activity modulation [39], [4
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br STAR Methods br Acknowledgments
2020-08-05
STAR★Methods Acknowledgments We thank J. Diffley for protein-expression strains and J. Sale, H. Williams, and members of the Yeeles lab for helpful discussions and comments on the manuscript. This work was supported by the Medical Research Council (MC_UP_1201/12). Introduction A variety of
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Statistical Analysis All graphical data were prepared
2020-08-05
Statistical Analysis: All graphical data were prepared and statistical analyses were performed using GraphPad Prism. Statistical significance between the differences of means was determined by performing a One-way Analysis of Variance followed by the Bonferroni\'s post-hoc test. Results CDK5 is
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Its auto inhibited structure contain N
2020-08-05
Its auto-inhibited structure contain N-terminus packed between residues of the glycine-rich loop, the activation loop and the αC helix. Both its N and C termini wrapping around the αC helix and the JM domain adopts a twisted hairpin conformation (Fig. 2.1B). The exclusive and unphosphorylated tyrosi
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Other karyopherins besides CRM must bind to
2020-08-05
Other karyopherins besides CRM1 must bind to FG-Nups in a similar fashion. However, at an atomic resolution, only the interaction of importin β with isolated FG motifs has been analyzed (Bayliss et al., 2000, Bayliss et al., 2002, Liu and Stewart, 2005). Despite similarities in the FG-binding pocket
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Studies have shown that the cultivation of BMSCs
2020-08-04
Studies have shown that the cultivation of BMSCs under hypoxic conditions, treating with cytokines (such as HGF, IGF-1 and IL-6) and viral-mediated CXCR-4 gene delivery have been shown to re-establish CXCR-4 expression on the surface of stem Apoptosis Inhibitor (Liu et al., 2010, Liu et al., 2014a,
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Forskolin is a labdane diterpene produced from the root of
2020-08-04
Forskolin is a labdane diterpene produced from the root of Coleus forskohlii (Bhat et al., 1977). Its extract has been recorded in Ayurveda medicine since ancient times and its medicinal value has been studied since early-1980s (Bristow et al., 1984; Kavitha et al., 2010). Early studies have suggest
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To overcome the drawbacks of
2020-08-04
To overcome the drawbacks of previous techniques in small satellite applications, we propose a generic high-performance and low-overhead SCFC technique named bipartite graph-based control flow checking (BGCFC). BGCFC partitions the target program into basic blocks and builds its control flow graph a
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br Tumor inhibitors targeting EphB
2020-08-04
Tumor inhibitors targeting EphB4 EphB4 inhibitors have been studied over the past several years, with many different approaches used to test for inhibition of activity or competitive binding affinity as a novel therapeutic modality to treat malignancy. Several potent Eph kinase inhibitors were re
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br The invasion of extravillous trophoblast EVT into the dec
2020-08-04
The invasion of extravillous trophoblast (EVT) into the decidualized endometrium is crucial in the determination of pregnancy outcome. Inadequate trophoblast invasion not only leads to implantation failure and spontaneous pregnancy loss but also results in the insufficient remodeling of spiral Cef
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Because the ubiquitin system is indispensable for immune
2020-08-04
Because the ubiquitin system is indispensable for immune responses, it has become an important target for pathogens to escape the host immune defenses (Kim et al., 2005; Li et al., 2016). For example, effector OspG of Shigella flexneri could bind many ubiquitinated E2 proteins, such as UbcH5 and Ubc
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br Results and discussion br
2020-08-04
Results and discussion Conclusion Based on the structure of ThDP, in this study, a series of novel ThDP analogs 6a-6g and 8a-8g were designed by optimizing triazole-benzene linker and modifying the substituent group of triazole ring. Then they were synthesized as potential inhibitors of Cy-PDH
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monocrotaline br Introduction The ubiquitination status of a
2020-08-04
Introduction The ubiquitination status of a target protein is achieved via a delicate balance between two opposing forces: ubiquitin E3 ligases and DUBs. It has been postulated that the majority of monocrotaline in a cell are regulated and modified by ubiquitin at some point (Hershko and Ciechan
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