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br Results and discussion br
2020-08-04
Results and discussion Conclusion Based on the structure of ThDP, in this study, a series of novel ThDP analogs 6a-6g and 8a-8g were designed by optimizing triazole-benzene linker and modifying the substituent group of triazole ring. Then they were synthesized as potential inhibitors of Cy-PDH
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monocrotaline br Introduction The ubiquitination status of a
2020-08-04
Introduction The ubiquitination status of a target protein is achieved via a delicate balance between two opposing forces: ubiquitin E3 ligases and DUBs. It has been postulated that the majority of monocrotaline in a cell are regulated and modified by ubiquitin at some point (Hershko and Ciechan
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liothyronine sodium The in vivo anti inflammatory effect of
2020-08-04
The in vivo anti-inflammatory effect of liothyronine sodium was further completed using the functional model of adjuvant induced arthritis (AIA) in rats as shown in . Compound was shown to be active in the AIA model, although with a lower potency than teriflunomide. These results are not surpris
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Industrial fermentation aims to produce valuable products fr
2020-08-04
Industrial fermentation aims to produce valuable products from cheap feedstocks by utilizing diverse microbial functions through aerobic or anaerobic fermentation [[8], [9], [10]]. During anaerobic fermentation, the reducing power is mostly directed to product synthesis rather than being oxidized, r
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The cardiotoxicity of NSAIDs except
2020-08-03
The cardiotoxicity of NSAIDs, except for aspirin, are well reported in many studies, and the food and drug administration (FDA) of the USA warned about the cardiovascular toxicities of NSAIDs [6]. NSAID treatment is associated with elevated blood pressure, stroke, and myocardial infarction [6,7]. Al
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Perturbation in the cytokine network is correlated with disr
2020-08-03
Perturbation in the cytokine network is correlated with disruption of growth hormone and glucocorticoid (GC) homeostasis (Thissen and Verniers, 1997; Sahid El-Radhi et al., 2000; Waxman and Holloway, 2009; Zhao et al., 2014), with important physiological consequences because cytokines affect the reg
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Other binding sites for Ub have been identified on
2020-08-03
Other JNJ-10198409 for Ub have been identified on RBR E3s that involve domains outside the RBR module. These are idiosyncratic to a particular RBR and likely impart special functionality. They are also unlikely to involve a Ub that is conjugated to an E2. For example, the relevant Ub to bind at the
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Coactivator binding induces substantial APC C conformational
2020-08-03
Coactivator binding induces substantial APC/C conformational changes that globally shift the platform and catalytic core into proximity of the substrate-binding module and increase the mobility of domains contributing to catalysis 21, 24 (Figures 2 A and 4 B). Most strikingly, repositioning of APC4
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Literatures show that fluoride affects diverse signaling pat
2020-08-03
Literatures show that fluoride affects diverse signaling pathways associated with proliferation and apoptosis, such as mitogen-activated protein kinase (MAPK), p53, activator protein-1 (AP-1) and nuclear factor kappa B (NF-κB) pathways (Iwatsuki and Matsuoka, 2016; Zhang et al., 2007, 2008). It is a
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One of the mechanisms contributing
2020-08-03
One of the mechanisms contributing to morphine tolerance is uncoupling of G-protein occurs from opioid receptors, resulting in a lower analgesic response. Our previous findings in morphine tolerant neonatal rats indicate that G-protein stimulation in the brain was significantly attenuated during to
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Endothelial NO synthesis is regulated by
2020-08-03
Endothelial NO synthesis is regulated by wide variety of humoral (eg. bradykinin, insulin, adiponectin, estrogen), mechanical (eg. shear stress) and pharmacological stimuli (eg. statins). Bradykinin is an important determinant of vascular function and regulates eNOS activity and expression during hy
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The enzymes involved in lipid biosynthesis pathways have att
2020-08-03
The enzymes involved in lipid biosynthesis pathways have attracted considerable interest as potential targets for disruption of aberrant lipid accumulation and its resulting impact on a range of disease states.8, 9 Triglyceride biosynthesis and the resulting lipid burden placed on tissues are largel
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CRM mediates the nuclear export
2020-07-31
CRM1 mediates the nuclear export of proteins and messenger RNAs, and is thus an important regulator of the subcellular distribution of key molecules. An increasingly large number of cancer-associated proteins that shuttle into and out of the nucleus, such as tumor suppressor and oncogenic proteins,
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br Acknowledgements This study was supported by the Science
2020-07-31
Acknowledgements This study was supported by the Science Fund for Creative Research Groups of Gansu Province (Grant No.1210RJIA006) and the National Key Project of Scientific and Technical Supporting Program (No.2007BAD40B04) and was partially supported by the National Beef Cattle and Yak Industr
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A recent study reports the expression
2020-07-31
A recent study reports the expression of glutathione-dependent enzymes (GGT, GST-isoforms, gamma-glutamylcysteine synthetase, glutathione disulfide reductase and GSH peroxidase) in human primary PT CP 154526 in four subsequent passages [33]. In this study, we present phase I and II activities at mul
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